Compensatory renal hypertrophy in hypophysectomized rats
نویسندگان
چکیده
منابع مشابه
Macromolecular Metabolism in Compensatory Renal Hypertrophy
1. The initial biochemical changes of compensatory hypertrophy occur well within 1 hour of unilateral nephrectomy and perhaps within the first few minutes.2. The initial increment in rRNA is from decreased metabolism rather than from increased synthesis.3. Changes in the processing of mRNA precursors are probably also important.4. Compensatory hypertrophy is regulated by a humoral stimulus or s...
متن کاملMessenger RNA in Compensatory Renal Hypertrophy
Experiments that deal with the stability of messenger RNA (mRNA) in normal mouse kidney, and, to some extent, the stability of mRNA during renal growth will be described. We have found a population of mRNA in the cytoplasm of mouse kidney that is short-lived. Such a class of rapidly metabolized mRNA could play an adaptive role at the translational or cytoplasmic level in determining gene expres...
متن کاملNitric oxide in serum and renal tissue during compensatory renal hypertrophy in rats.
Nitric oxide (NO) level in serum and renal tissue has been examined in 15 male Wistar rats, body weight 200-250 g, 7 days after unilateral nephrectomy. All rats were ether-anaesthetized and the kidneys were removed by dorsolateral approach. NO concentration in serum and renal tissue was determined by classic colorimetric Griess reaction. Conversion of NO(3)(2-) into NO(2)(2-) was done with elem...
متن کاملChemical aspects of compensatory renal hypertrophy.
has been known for over a century that when 1 of the kidneys of a laboratory animal has been surgically removed or is not functioning properly, its partner undergoes a compensatory hypertrophy in which both cell size and cell number increase (20, 21, 33). The mechanism of this compensatory growth is unknown. An obvious possi bility is that it is due to a single kidney having to carry out the wo...
متن کاملFunctional correlates of compensatory renal hypertrophy.
The functional correlates of compensatory renal hypertrophy were studied by micropuncture techniques in rats after the removal of one kidney. The glomerular filtration rate increased to roughly the same extent in the whole kidney and in individual surface nephrons, resulting in a greater amount of sodium delivered to the tubules for reabsorption. The fraction of the glomerular filtrate absorbed...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1977
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1977.sp012091